Sequencing the entire genome will change pregnancy

World Pregnancy will be changed radically, predicts Noir Siddikui. “I think the default way will decide that they have children is over IVF and embryo screening,” she said on Wired health Summit last week. “There is only a massive amount of risk that you can download from the table.”

Siddiku is the founder and executive director of orchids, a biotechnical company that offers Screening of the entire genome From the embryo for IVF. Analysis of DNA of different embryos before choosing which is in implant, it says that parents can lower the risk, their children grow up with incentive conditions with a genetic basis. Siddiku talked to George Church-a-pioneer in Genomics and Professor Genetics at Harvard Medical School – at the Summit in Boston, exploring the promise and potential of the sequence of the entire genome.

An estimated 4 percent of people around the world have a disease caused by a single genetic mutation. With the embryonic screen, “these monogenic diseases can be completely avoided,” Siddiku said. On top of this, about half of the world’s population suffers from chronic illness with at least a genetic basis. Analyze five embryos that are in front of the IPLANTING, said Siddiku, “you can now reduce the genetic component of that risk by these two-digit numbers. 30 percent and at best and at best and at best.”

Orchid’s website, which references Statistical analysis on how much risk reduction can be achieved through screening embryos, it explains that the exact decrease in relative risk will depend on a number of factors. They include, among other things, how the disease prevails, the number of embryos analyzed and how much influence on genetic variants are shown in the probability of developing the disease.

The church is an investor in orchid and believes that the type of embryo screening is offered among the most constructive medical technologies that have ever been created. The human genome project, the first effort to map all human genes, costs $ 3 billion, but since then the costs of the sequencing genome have drastically fell. Orchy order of the entire genome costs several thousand dollars per embryo. It is “perhaps 10 times the return of investment,” the church believes. “The huge part of our health care costs, psychological problems and family issues could be resolved by this method.”

Siddiku used technology for your embryo. She shared the story of her mother, who experienced blindness for adults as a result of a genetic variation in her genome. “Fortunately, all embryos are negative for that,” she said. “But another thing that is quite common in most southern Asian families is an incredibly high risk for heart disease and diabetes. So, it is a second thing we apply on the basis on the basis of which we priority we ask.”

The secondance of Siddiku described by monogenic, which means that he caused only a unique genetic variation. Unique diseases known, “95 percent have no treatment, much smaller medicine,” Siddiku said. But many other conditions – such as schizophrenia or bipolar disorder or heart disease – are polygenical, guided by the cumulative influence of many genetic variants. For this, genetic risk results can quantify the risk of potentially developing diseases and can also be calculated for adults and embryos. The embryos of orchid tests are looking for both types of diseases.