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When treating heavy Burns and trauma, skin regeneration can be a thing of life or death. Extensive burns are usually treated by transplanting the thin layer of epidermis, upper layer of the skin, from somewhere else on the body. However, this method not only leaves large scars, it also does not return the skin to its original functional condition. If the dermis, the layer below the epiderma, which contains blood vessels and nerves, cannot be considered a normal wire.
Now the work of Swedish researchers may have approached drugs closer to opportunities to regenerate live skin. They have developed two types of 3D techniques for bioprinting to artificially generate thick skin that is vascular, meaning it contains blood vessels. One technique produces skin that is full of cells, and the other produces arbitrarily shaped blood vessels in tissue. The two technologies take different approaches to the same challenge. Accessions entered in two studies Published in Advanced Healthcare Materials magazine.
“Dermis is so complicated that we cannot grow in the laboratory. We do not even know all its components,” Johan Junker, Associate Professor at University of Linkoping and Specialist in Plastic leading this work, in a statement. “That’s why we’re too much, they think we could adjudicate the construction blocks and then let the body make himself a dermic.”
Junker and his team were designed by a “ion” ink in which fibroblasts of cells produced by dermal components such as collagen, elastin and hyaluronic acids are cultivated on a small grain surface and are stealing in hyaluronic acid. The construction of this ink three-dimensionally using 3D printers, they managed to create skin structure filled with high density cells at will.
In the transplant experiment using mice, researchers confirmed that live cells grow inside the tissue fragments made of this ink, excreting collagen and renewal of the dermis components. The new blood vessels also grew inside the graft, indicating that the conditions for strengthening long-term tissue are met.
Blood vessels play an extremely important role in building artificial tissues. No matter how much cells is cultivated to create a tissue model, without blood vessels, oxygen and nutrients cannot be carried evenly in all cells. And without blood vessels, as the tissue structure grows, cells in the middle of the tissue die.
The research team also created technology called refrainment (reorganizing free floating means of hydrogel), which enables flexible construction of blood vessels in artificial tissues by printing and arranging or hydrogels, a gel of 98 percent of water. These threads are much tighter than ordinary gel materials and can maintain shape even when they are tied or knitted. Moreover, they also have properties in the form of shapes that allow them to return to their original shape even when they are crushed.
